Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia - A GENFI study.

doi:10.1016/j.bbi.2024.08.030

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Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia - A GENFI study.

Brain, behavior, and immunity - 1 Nov 2024

Fenoglio Chiara, Serpente Maria, Arcaro Marina, Carandini Tiziana, Sacchi Luca, Pintus Manuela, Rotondo Emanuela, Borracci Vittoria, Ghezzi Laura, Bouzigues Arabella, Russell Lucy L, Foster Phoebe H, Ferry-Bolder Eve, van Swieten John C, Jiskoot Lize C, Seelaar Harro, Sánchez Valle Raquel, Laforce Robert, Graff Caroline, Vandenberghe Rik, de Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Gerhard Alexander, Levin Johannes, Sorbi Sandro, Otto Markus, Pasquier Florence, Ducharme Simon, Butler Chris R, Ber Isabelle Le, Finger Elizabeth, Carmela Tartaglia Maria, Masellis Mario, Rowe James B, Synofzik Matthis, Moreno Fermin, Borroni Barbara, Rohrer Jonathan D, Arighi Andrea, Galimberti Daniela

Abstract excerpt

BACKGROUND: Inflammation has been proposed as a crucial player in neurodegeneration, including Frontotemporal Dementia (FTD). A few studies on sporadic FTD lead to inconclusive results, whereas large studies on genetic FTD are lacking. The aim of this study is to determine cytokine and chemokine plasma circulating levels in a large cohort of genetic FTD, collected within the GENetic Frontotemporal dementia...

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PMID: 39153518
DOI: 10.1016/j.bbi.2024.08.030

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