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Article

Imaging Striatal Microglial Activation in Patients with Parkinson's Disease.

PloS one - 1 Jan 2015

Koshimori Yuko, Ko Ji-Hyun, Mizrahi Romina, Rusjan Pablo, Mabrouk Rostom, Jacobs Mark F, Christopher Leigh, Hamani Clement, Lang Anthony E, Wilson Alan A, Houle Sylvain, Strafella Antonio P

Abstract excerpt

This study investigated whether the second-generation translocator protein 18kDa (TSPO) radioligand, [18F]-FEPPA, could be used in neurodegenerative parkinsonian disorders as a biomarker for detecting neuroinflammation in the striatum. Neuroinflammation has been implicated as a potential mechanism for the progression of Parkinson's disease (PD). Positron Emission Tomography (PET) radioligand targeting for TSPO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26381267
DOI: 10.1371/journal.pone.0138721
PMCID: PMC4575151

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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