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Article

In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study.

Parkinsonism & related disorders - 1 Jul 2010

Miyoshi Michie, Shinotoh Hitoshi, Wszolek Zbigniew K, Strongosky Audrey J, Shimada Hitoshi, Arakawa Ryosuke, Higuchi Makoto, Ikoma Yoko, Yasuno Fumihiko, Fukushi Kiyoshi, Irie Toshiaki, Ito Hiroshi, Suhara Tetsuya

Abstract excerpt

BACKGROUND: Microglial activation and disrupted neurotransmissions may herald symptomatic manifestations in neurodegenerative tauopathies. METHODS: We investigated microglial activation with [(11)C]DAA1106 positron emission tomography (PET), striatal dopaminergic function with l-[beta-(11)C]dopa PET, acetylcholinesterase (AChE) activity with [(11)C]N-methylpiperidin-4-yl acetate PET, and morphologic brain changes...

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Source

Identifiers

PMID: 20452812
DOI: 10.1016/j.parkreldis.2010.04.004

Genes

PGC
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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