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Article

Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas.

PloS one - 1 Jan 2015

Patai Árpád V, Valcz Gábor, Hollósi Péter, Kalmár Alexandra, Péterfia Bálint, Patai Árpád, Wichmann Barnabás, Spisák Sándor, Barták Barbara Kinga, Leiszter Katalin, Tóth Kinga, Sipos Ferenc, Kovalszky Ilona, Péter Zoltán, Miheller Pál, Tulassay Zsolt, Molnár Béla

Abstract excerpt

Microarray analysis of promoter hypermethylation provides insight into the role and extent of DNA methylation in the development of colorectal cancer (CRC) and may be co-monitored with the appearance of driver mutations. Colonic biopsy samples were obtained endoscopically from 10 normal, 23 adenoma (17 low-grade (LGD) and 6 high-grade dysplasia (HGD)), and 8 ulcerative colitis (UC) patients (4 active and 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26291085
DOI: 10.1371/journal.pone.0133836
PMCID: PMC4546193

Genes

SFRP1
BNC1
BRAF
HGD
KRAS
MAL
SFRP2
SLIT2
SLIT3
SST
TMEFF2
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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