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Article

Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas

11 Mar 2011

Abstract excerpt

In our study, whole-genome methylation arrays were applied to identify novel genes with tumor specific DNA methylation of promoter CpG islands in pre-malignant and malignant colorectal lesions. Using a combination of Illumina HumanMethylation27 beadchips, Methylation-Sensitive High Resolution Melting (MS-HRM) analysis, and Exon arrays (Affymetrix) the DNA methylation pattern of ∼14,000 genes and their transcript...

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PMID: 21400501
DOI: 10.1002/ijc.25951

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