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Article

Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis.

Oncotarget - 20 Dec 2016

Takane Kiyoko, Matsusaka Keisuke, Ota Satoshi, Fukuyo Masaki, Yue Yao, Nishimura Motoi, Sakai Eiji, Matsushita Kazuyuki, Miyauchi Hideaki, Aburatani Hiroyuki, Nakatani Yukio, Takayama Tadatoshi, Matsubara Hisahiro, Akagi Kiwamu, Kaneda Atsushi

Abstract excerpt

While sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC and adenoma into three distinct subgroups: high-, intermediate-, and low-methylation epigenotypes. Here, we...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

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Source

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Identifiers

PMID: 27563825
DOI: 10.18632/oncotarget.11510
PMCID: PMC5356641

Genes

APC
FAP
BRAF
KRAS
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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