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Article

Accumulation of aberrant DNA methylation during colorectal cancer development.

World journal of gastroenterology - 28 Jan 2014

Sakai Eiji, Nakajima Atsushi, Kaneda Atsushi

Abstract excerpt

Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains to be one of the most common causes of cancer-related death. CRC arises through accumulation of multiple genetic and epigenetic alterations that transform normal colonic epithelium into adenocarcinomas. Among crucial roles of epigenetic alterations, gene silencing by aberrant DNA methylation of promoter regions is one of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24574770
DOI: 10.3748/wjg.v20.i4.978
PMCID: PMC3921549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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