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Article

Comprehensive DNA Methylation and Mutation Analyses Reveal a Methylation Signature in Colorectal Sessile Serrated Adenomas.

Pathology oncology research : POR - 1 Jul 2017

Patai Árpád V, Barták Barbara Kinga, Péterfia Bálint, Micsik Tamás, Horváth Réka, Sumánszki Csaba, Péter Zoltán, Patai Árpád, Valcz Gábor, Kalmár Alexandra, Tóth Kinga, Krenács Tibor, Tulassay Zsolt, Molnár Béla

Abstract excerpt

Colorectal sessile serrated adenomas (SSA) are hypothesized to be precursor lesions of an alternative, serrated pathway of colorectal cancer, abundant in genes with aberrant promoter DNA hypermethylation. In our present pilot study, we explored DNA methylation profiles and examined selected gene mutations in SSA. Biopsy samples from patients undergoing screening colonoscopy were obtained during endoscopic...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

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Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 27896617
DOI: 10.1007/s12253-016-0154-6

Genes

BNC1
BRAF
CALCA
DKK2
GALR2
MLH1
OPCML
PCDH10
PDLIM4
SFRP1
SFRP2
SLIT3
SST
TAC1
VIM
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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