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Article

Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists

29 Nov 2014

Abstract excerpt

BACKGROUND: There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage. Here, we investigated whether epigenetic silencing of Wnt antagonists is the biological driver for this increased Wnt activity in human tissues and how these methylation changes correlate with...

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PMID: 25432628
DOI: 10.1186/1471-2407-14-891

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