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Article

Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.

Journal of cell science - 15 Sept 2015

Singh Bhuminder, Bogatcheva Galina, Starchenko Alina, Sinnaeve Justine, Lapierre Lynne A, Williams Janice A, Goldenring James R, Coffey Robert J

Abstract excerpt

Directed delivery of EGF receptor (EGFR) ligands to the apical or basolateral surface is a crucial regulatory step in the initiation of EGFR signaling in polarized epithelial cells. Herein, we show that the EGFR ligand betacellulin (BTC) is preferentially sorted to the basolateral surface of polarized MDCK cells. By using sequential truncations and site-directed mutagenesis within the BTC cytoplasmic domain,...

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Source

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Identifiers

PMID: 26272915
DOI: 10.1242/jcs.170852
PMCID: PMC4582402

Genes

BTC
EGFR
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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