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Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor

17 Oct 2022

Abstract excerpt

Abstract Overexpression and/or overactivation of the Epidermal Growth Factor Receptor (EGFR) is oncogenic in several tumor types yet targeting the kinase domain of wildtype EGFR has had limited success. EGFR has numerous kinase-independent roles, one of which is accomplished through the Sorting Nexin-dependent retrotranslocation of EGFR to the nucleus, which is observed in some metastatic cancers and...

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PMID: 36253541
DOI: 10.1038/s41417-022-00541-7

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