Article

Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactions

2020-09-13

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are frequently driven by insertions and deletions within the gene encoding calreticulin (CRT). CRT Del52 and CRT Ins5 are recurrent mutations. Although oncogenic transformation requires both mutated CRT and the myeloproliferative leukemia protein (Mpl), the molecular mechanism of CRT-mediated constitutive activation of Mpl is unknown. Our studies reveal that the novel C-domain...

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Literature Corpus work: 5c041d94-5998-53dc-81fa-bb947b9e16fb
DOI: 10.1101/2020.09.13.295485

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