Article
EGF receptor trafficking: consequences for signaling and cancer.
Trends in cell biology - 1 Jan 2014
Tomas Alejandra, Futter Clare E, Eden Emily R
Abstract excerpt
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of that traffic in signal transduction. Although such studies have largely focused on mitogenic signaling and dysregulated traffic in tumorigenesis, there is growing interest in the potential role of EGFR traffic in cell survival and the...
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