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Article

E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin.

The Journal of biological chemistry - 17 May 2013

Jenkins Paul M, Vasavda Chirag, Hostettler Janell, Davis Jonathan Q, Abdi Khadar, Bennett Vann

Abstract excerpt

We report a highly conserved motif in the E-cadherin juxtamembrane domain that determines apical-lateral polarity by conferring both restricted mobility at the lateral membrane and transcytosis of apically mis-sorted protein to the lateral membrane. Mutations causing either increased lateral membrane mobility or loss of apical-lateral transcytosis result in partial mis-sorting of E-cadherin in Madin-Darby canine...

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Identifiers

PMID: 23530049
DOI: 10.1074/jbc.M113.454439
PMCID: PMC3656260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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