Article

Coiled coil control of growth factor and inhibitor-dependent EGFR trafficking and degradation

2020-12-11

Abstract excerpt

EGFR exhibits biased signaling, whereby growth factor or mutation-dependent changes in receptor conformation and/or dynamics elicit distinct intracellular outcomes. We report that many outcomes associated with activated EGFR are controlled by a two-state coiled coil switch located within the juxtamembrane segment (JM), an essential component of the cytosolic dimer interface. The position of this switch defines the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cd3fdf6-8a16-53ff-816d-dfc4a44157e0
DOI: 10.1101/2020.12.10.419739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coiled coil control of growth factor and inhibitor-dependent EGFR trafficking and degradationDOI 10.1101/2020.12.10.419739Read

Discrete Coiled Coil Rotamers Form within the EGFRvIII Juxtamembrane Domain.Semantic proximity Read

Inhibiting epidermal growth factor receptor at a distance.Semantic proximity Read

Mechanisms of Action of EGFR Tyrosine Kinase Receptor Incorporated in Extracellular VesiclesSemantic proximity Read

Intrinsically disordered ligands for the control of receptor uptake by endocytosisSemantic proximity Read

Allosteric Inhibition of the Epidermal Growth Factor Receptor.Semantic proximity Read

The MET Oncogene Network of Interacting Cell Surface ProteinsSemantic proximity Read

Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.Semantic proximity Read

Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.Semantic proximity Read

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.Semantic proximity Read

A threshold model for receptor tyrosine kinase signaling specificity and cell fate determinationSemantic proximity Read

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptorSemantic proximity Read

Analysis of EGFR binding hotspots for design of new EGFR inhibitory biologicsSemantic proximity Read