Article
Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein.
American journal of physiology. Cell physiology - 1 Feb 2006
Klapper Maja, Daniel Hannelore, Döring Frank
Abstract excerpt
The peptide transporter PEPT2 is a polytopic transmembrane protein that mediates the cellular uptake of di- and tripeptides and a variety of peptidomimetics. It is widely expressed in mammalian tissues, including kidney, lung, mammary gland, choroid plexus, and glia cells. In renal tubular cells, PEPT2 is exclusively found at the apical membrane. The molecular mechanisms underlying this polarized expression and...
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