Article
Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease.
Seminars in arthritis and rheumatism - 1 Dec 2022
Wheeler Austin M, Baker Joshua F, Poole Jill A, Ascherman Dana P, Yang Yangyuna, Kerr Gail S, Reimold Andreas, Kunkel Gary, Cannon Grant W, Wysham Katherine D, Singh Namrata, Lazaro Deana, Monach Paul, Bridges S Louis, Mikuls Ted R, England Bryant R
Abstract excerpt
OBJECTIVE: MUC5B and TOLLIP single nucleotide polymorphisms (SNPs) and cigarette smoking were associated with rheumatoid arthritis-interstitial lung disease (RA-ILD) in a predominantly Northern European population. We evaluated whether RA-ILD is associated with these genetic variants and HLA-DRB1 shared epitope (SE) alleles in a large RA cohort stratified by race and smoking history. METHODS: HLA-DRB1 SE alleles...
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