Article
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Feb 2011
Padyukov Leonid, Seielstad Mark, Ong Rick T H, Ding Bo, Rönnelid Johan, Seddighzadeh Maria, Alfredsson Lars, Klareskog Lars
Abstract excerpt
BACKGROUND: Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data from genome-wide association studies (GWAS) have only been published from ACPA-positive subsets of RA or from studies that have not separated the two subsets. The aim of the current study is to provide and compare GWAS data for both...
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