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Article

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition.

Molecular biology of the cell - 1 Oct 2015

Ogi Hiroo, Goto Greicy H, Ghosh Avik, Zencir Sevil, Henry Everett, Sugimoto Katsunori

Abstract excerpt

Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain. In budding yeast, ATM and ATR correspond to Tel1 and Mec1, respectively. In this study, we characterized functions of the FATC domain of Tel1 by introducing substitution...

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Source

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Identifiers

PMID: 26246601
DOI: 10.1091/mbc.E15-05-0259
PMCID: PMC4591692

Genes

ATM
ATR
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition.PMID 26246601Read ↗

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