TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.

doi:10.1038/srep36913

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Article

TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.

Scientific reports - 14 Nov 2016

Ho Angus, Wilson Florence R, Peragine Stephanie L, Jeyanthan Kajaparan, Mitchell Taylor R H, Zhu Xu-Dong

Abstract excerpt

TRF1, a component of the shelterin complex, plays a key role in both telomerase-dependent telomere maintenance and alternative lengthening of telomeres, the latter also known as ALT. Characteristics of ALT cells include C-circles and ALT-associated PML bodies, referred to as APBs. The function of TRF1 is tightly regulated by post-translational modification including phosphorylation, however TRF1 phosphorylation...

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PMID: 27841304
DOI: 10.1038/srep36913
PMCID: PMC5107961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.