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Article

Activation of protein kinase Tel1 through recognition of protein-bound DNA ends.

Molecular and cellular biology - 1 May 2011

Fukunaga Kenzo, Kwon Youngho, Sung Patrick, Sugimoto Katsunori

Abstract excerpt

Double-strand breaks (DSBs) in chromosomal DNA elicit a rapid signaling response through the ATM protein kinase. ATM corresponds to Tel1 in budding yeast. Here we show that the catalytic activity of Tel1 is altered by protein binding at DNA ends via the Mre11-Rad50-Xrs2 (MRX) complex. Like ATM, Tel1 is activated through interaction with the MRX complex and DNA ends. In vivo, Tel1 activation is enhanced in sae2Δ...

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Source

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Identifiers

PMID: 21402778
DOI: 10.1128/MCB.05157-11
PMCID: PMC3133365

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Activation of protein kinase Tel1 through recognition of protein-bound DNA ends.PMID 21402778Read ↗

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.Semantic proximity Read ↗

ATM specifically mediates repair of double-strand breaks with blocked DNA endsSemantic proximity Read ↗

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.Semantic proximity Read ↗

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joiningSemantic proximity Read ↗

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends.Semantic proximity Read ↗

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition.Semantic proximity Read ↗

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaksSemantic proximity Read ↗

Mechanism of MRX inhibition by Rif2 at telomeres.Semantic proximity Read ↗

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signalingSemantic proximity Read ↗

ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restartSemantic proximity Read ↗

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.Semantic proximity Read ↗

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaksSemantic proximity Read ↗

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