Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.

Nucleic acids research - 1 Jun 2009

Tseng Shun-Fu, Shen Zih-Jie, Tsai Hung-Ji, Lin Yi-Hsuan, Teng Shu-Chun

Abstract excerpt

Budding yeast telomerase is mainly activated by Tel1/Mec1 (yeast ATM/ATR) on Cdc13 from late S to G2 phase of the cell cycle. Here, we demonstrated that the telomerase-recruitment domain of Cdc13 is also phosphorylated by Cdk1 at the same cell cycle stage as the Tel1/Mec1-dependent regulation. Phosphor-specific gel analysis demonstrated that Cdk1 phosphorylates residues 308 and 336 of Cdc13. The residue T308 of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2 Protein Kinase
Share to Cell Cycle
Share to Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Protein Stability

Share to Saccharomyces cerevisiae Proteins

Share to Telomere

Share to Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19359360
DOI: 10.1093/nar/gkp235
PMCID: PMC2699520

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.PMID 19359360Read ↗

The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.Semantic proximity Read ↗

Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation.Semantic proximity Read ↗

Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.Semantic proximity Read ↗

TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

New function of CDC13 in positive telomere length regulation.Semantic proximity Read ↗

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition.Semantic proximity Read ↗

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.Semantic proximity Read ↗

Protein kinase C controls activation of the DNA integrity checkpoint.Semantic proximity Read ↗

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein HomeostasisSemantic proximity Read ↗

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.