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Article

Mec1 function in the DNA damage response does not require its interaction with Tel2.

Cell cycle (Georgetown, Tex.) - 1 Dec 2008

Anderson Carol M, Blackburn Elizabeth H

Abstract excerpt

The essential, conserved Tel2 protein plays a role in the response to DNA damage and replication stress in a wide range of eukaryotes. Tel2 interacts physically with multiple members of the PI3-kinase related protein kinase (PIKK) family in mammalian cells and fission yeast. In mammalian cells, loss of Tel2 leads to destabilization of PIKKs. Our previous work in the yeast Saccharomyces cerevisiae showed that Tel2...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19029808
DOI: 10.4161/cc.7.23.7154
PMCID: PMC2839897

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mec1 function in the DNA damage response does not require its interaction with Tel2.PMID 19029808Read ↗

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Semantic proximity Read ↗

Tel2 regulates the stability of PI3K-related protein kinases.Semantic proximity Read ↗

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.Semantic proximity Read ↗

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Semantic proximity Read ↗

A tti1 mutation in the Tel2-Tti1-Tti2 complex specifically eliminates the cellular function of Rad3ATR, but not that of other PIKKs in fission yeast.Semantic proximity Read ↗

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition.Semantic proximity Read ↗

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Semantic proximity Read ↗

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.Semantic proximity Read ↗

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein HomeostasisSemantic proximity Read ↗

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.Semantic proximity Read ↗

Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.Semantic proximity Read ↗

Kinase-independent functions of TEL1 in telomere maintenance.Semantic proximity Read ↗

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