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Article

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.

Genetics - 1 Jun 2002

Craven Rolf J, Greenwell Patricia W, Dominska Margaret, Petes Thomas D

Abstract excerpt

In eukaryotes, a family of related protein kinases (the ATM family) is involved in regulating cellular responses to DNA damage and telomere length. In the yeast Saccharomyces cerevisiae, two members of this family, TEL1 and MEC1, have functionally redundant roles in both DNA damage repair and telomere length regulation. Strains with mutations in both genes are very sensitive to DNA damaging agents, have very...

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Source

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Identifiers

PMID: 12072449
DOI: 10.1093/genetics/161.2.493
PMCID: PMC1462148

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.PMID 12072449Read ↗

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.Semantic proximity Read ↗

ATM function and telomere stability.Semantic proximity Read ↗

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.Semantic proximity Read ↗

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA Damage and Replication Stress CheckpointsSemantic proximity Read ↗

TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints.Semantic proximity Read ↗

Effects of Saccharomyces cerevisiae mec1, tel1, and mre11 mutations on spontaneous and methylmethane sulfonate-induced genome instability.Semantic proximity Read ↗

The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells.Semantic proximity Read ↗

Mec1ATR is needed for extensive telomere elongation in response to ethanol in yeast.Semantic proximity Read ↗

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Semantic proximity Read ↗

Mec1 function in the DNA damage response does not require its interaction with Tel2.Semantic proximity Read ↗

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