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Article

An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.

PLoS genetics - 1 Jan 2013

Zhou Zhong-Wei, Liu Cong, Li Tang-Liang, Bruhn Christopher, Krueger Anja, Min WooKee, Wang Zhao-Qi, Carr Antony M

Abstract excerpt

ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins - Dpb11(TopBP1), Ddc1(Rad9) and Dna2 - all interact with and activate Mec1(ATR). Each contains an ATR activation domain (ADD) that interacts directly with the Mec1(ATR):Ddc2(ATRIP) complex. Any of the Dpb11(TopBP1), Ddc1(Rad9) or Dna2 ADDs is sufficient to activate Mec1(ATR) in vitro....

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Identifiers

PMID: 23950734
DOI: 10.1371/journal.pgen.1003702
PMCID: PMC3738440

Genes

ATR
ATRIP

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Related research

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An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.PMID 23950734Read ↗

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