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Article

Telomere shortening triggers a feedback loop to enhance end protection.

Nucleic acids research - 21 Aug 2017

Yang Chia-Wei, Tseng Shun-Fu, Yu Chia-Jung, Chung Chia-Yu, Chang Cheng-Yen, Pobiega Sabrina, Teng Shu-Chun

Abstract excerpt

Telomere homeostasis is controlled by both telomerase machinery and end protection. Telomere shortening induces DNA damage sensing kinases ATM/ATR for telomerase recruitment. Yet, whether telomere shortening also governs end protection is poorly understood. Here we discover that yeast ATM/ATR controls end protection. Rap1 is phosphorylated by Tel1 and Mec1 kinases at serine 731, and this regulation is stimulated...

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Identifiers

PMID: 28575419
DOI: 10.1093/nar/gkx503
PMCID: PMC5737367

Genes

ATM
ATR

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