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Article

A tti1 mutation in the Tel2-Tti1-Tti2 complex specifically eliminates the cellular function of Rad3ATR, but not that of other PIKKs in fission yeast.

PLoS genetics - 1 Jun 2026

Bhadra Sankhadip, Ahamad Nafees, Khan Saman, Xu Yong-Jie

Abstract excerpt

The Tel2-Tti1-Tti2, or TTT complex, is the co-chaperone for co-translational maturation of all phosphatidylinositol 3-kinase-related kinases (PIKKs). The complex is highly conserved in eukaryotes and controls multiple cellular processes through PIKKs. Mutations of the TTT complex have recently been linked to disease syndromes and cancer. In Schizosaccharomyces pombe, six PIKKs are expressed: Rad3ATR, Tel1ATM,...

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Identifiers

PMID: 42275414
DOI: 10.1371/journal.pgen.1012206
PMCID: PMC13274921

Genes

TRRAP

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