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Article

No significant impact of IFN-γ pathway gene variants on tuberculosis susceptibility in a West African population.

European journal of human genetics : EJHG - 1 May 2016

Meyer Christian G, Intemann Christopher D, Förster Birgit, Owusu-Dabo Ellis, Franke Andre, Horstmann Rolf D, Thye Thorsten

Abstract excerpt

The concept of interferon-γ (IFN-γ) having a central role in cell-mediated immune defence to Mycobacterium tuberculosis has long been proposed. Observations made through early candidate gene studies of constituents of the IFN-γ pathway have identified moderately associated variants associated with resistance or susceptibility to tuberculosis (TB). By analysing 20 major genes whose proteins contribute to IFN-γ...

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Source

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Identifiers

PMID: 26242990
DOI: 10.1038/ejhg.2015.172
PMCID: PMC4930082

Genes

IFNGR1
EBI3
IFNG
IFNGR2
JAK2
SOCS1
STAT1
STAT4
TBX21
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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