Article
No association between interferon-gamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample.
Thorax - 1 Apr 2004
Awomoyi A A, Nejentsev S, Richardson A, Hull J, Koch O, Podinovskaia M, Todd J A, McAdam K P W J, Blackwell J M, Kwiatkowski D, Newport M J
Abstract excerpt
BACKGROUND: Tuberculosis (TB) is a major global cause of mortality and morbidity, and host genetic factors influence disease susceptibility. Interferon-gamma mediates immunity to mycobacteria and rare mutations in the interferon-gamma receptor-1 gene (IFNGR1) result in increased susceptibility to mycobacterial infection, including TB, in affected families. The role of genetic variation in IFNGR1 in susceptibility...
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