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Article

Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

American journal of respiratory and critical care medicine - 1 Aug 2006

Cooke Graham S, Campbell Sarah J, Sillah Jackson, Gustafson Per, Bah Boubacar, Sirugo Georgio, Bennett Steve, McAdam Keith P W J, Sow Oumou, Lienhardt Christian, Hill Adrian V S

Abstract excerpt

RATIONALE: Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations have been identified in the IFN-gamma signaling pathway that predispose to severe mycobacterial disease, but the relevance of polymorphism within these genes to the commo...

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Source

Identifiers

PMID: 16690980
DOI: 10.1164/rccm.200601-088OC

Genes

IFNG
IFNGR1
IFNGR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16690980-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.PMID 16690980Read ↗

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No association between interferon-gamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample.Semantic proximity Read ↗

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IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study.Semantic proximity Read ↗

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosisSemantic proximity Read ↗

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