Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.

doi:10.1093/infdis/jiu140

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Article

Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.

The Journal of infectious diseases - 15 Aug 2014

Sabri Ayoub, Grant Audrey V, Cosker Kristel, El Azbaoui Safa, Abid Ahmed, Abderrahmani Rhorfi Ismail, Souhi Hicham, Janah Hicham, Alaoui-Tahiri Kebir, Gharbaoui Yasser, Benkirane Majid, Orlova Marianna, Boland Anne, Deswarte Caroline, Migaud Melanie, Bustamante Jacinta, Schurr Erwin, Boisson-Dupuis Stephanie, Casanova Jean-Laurent, Abel Laurent, El Baghdadi Jamila

Abstract excerpt

BACKGROUND: Only a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M. tuberculosis, underlined the importance of the interleukin 12 (IL-12)/interferon γ...

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PMID: 24610875
DOI: 10.1093/infdis/jiu140
PMCID: PMC4111910

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STAT4

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