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Article

Rare STAT1 variants in Moroccan tuberculosis patients: insights into host genetic susceptibility.

Clinical and experimental immunology - 6 Jan 2026

Zaidi Sanae, Rafik Aniss, Skhoun Hanaa, Elkarhat Zouhair, Guennoun Aya, Tabehout Fatima, Errami Abderrahmane, Abid Ahmed, Abderrhamani Ghorfi Ismail, El Ouazzani Hanane, Souhi Hicham, Zegmout Adil, El Hassani Amal, Ailal Fatima, Abilkassem Rachid, Ouzzif Zohra, Benhsaien Ibtihal, Bousfiha Ahmed Aziz, El Baghdadi Jamila

Abstract excerpt

Tuberculosis (TB) remains a major public health concern, particularly in Morocco. The JAK/STAT signaling pathway, activated by interferon-gamma (IFN-γ), plays a crucial role in the immune response against intracellular mycobacteria. However, pathogenic variants in the STAT1 gene can lead to either impaired or dysregulated signaling, affecting host defense mechanisms. In this study, we investigated 245 patients...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41660815
DOI: 10.1093/cei/uxag006
PMCID: PMC12927499

Genes

STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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