Article
Association study of polymorphisms in interferon-γ receptor genes with the risk of pulmonary tuberculosis.
Molecular medicine reports - 1 Jul 2015
Shin Joong-Gon, Park Byung Lae, Kim Lyoung Hyo, Namgoong Suhg, Kim Ji On, Chang Hun Soo, Park Jong Sook, Jang An Soo, Park Sung Woo, Kim Do Jin, Kim Ki Up, Kim Yang Gee, Uh Soo-Taek, Seo Ki Hyun, Kim Young Hoon, Koh Insong, Park Choon Sik, Shin Hyoung Doo
Abstract excerpt
Tuberculosis (TB) is an infectious disease caused by mycobacterium, which most commonly affects the lungs. The adaptive immune response in Mycobacterium tuberculosis is predominantly mediated by the interferon-γ (IFN-γ) signaling pathway, which is regulated by IFN-γ receptors (IFNGR). IFN-γ activates the transcription of a number of genes that are important in immune responses, thus the appropriate function of...
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