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Article

Clinical implications of interferon-γ genetic and epigenetic variants.

Immunology - 1 Dec 2014

Smith Nicola L D, Denning David W

Abstract excerpt

Interferon-γ (IFN-γ) is an integral and critical molecule of the immune system, with multiple functions, mostly related to the T helper type 1 (Th1) response to infection. It is critical for defence against mycobacterial infection and is of increasing interest in defence against fungi. In this article, we review the genetic and epigenetic variants affecting IFN-γ expression and investigate its role in disease,...

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Identifiers

PMID: 25052001
DOI: 10.1111/imm.12362
PMCID: PMC4253498

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