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Article

Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2007

Sahiratmadja Edhyana, Baak-Pablo Renee, de Visser Adriëtte W, Alisjahbana Bachti, Adnan Iskandar, van Crevel Reinout, Marzuki Sangkot, van Dissel Jaap T, Ottenhoff Tom H M, van de Vosse Esther

Abstract excerpt

Upon infection with mycobacteria the IL-12/IFN-gamma axis plays an essential role in the activation of cell-mediated immunity required for the elimination of pathogens. Mutations in genes of the IL-12/IFN-gamma axis are known to cause extreme susceptibility to infection with environmental mycobacteria, and subtle variations in these genes may influence susceptibility to more virulent mycobacteria. We analyzed the...

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Source

Identifiers

PMID: 17392024
DOI: 10.1016/j.tube.2007.02.001

Genes

IFNGR1
IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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