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Article

Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity.

Human mutation - 1 Jun 2011

Manry Jérémy, Laval Guillaume, Patin Etienne, Fornarino Simona, Tichit Magali, Bouchier Christiane, Barreiro Luis B, Quintana-Murci Lluis

Abstract excerpt

Identifying how natural selection has affected immunity-related genes can provide insights into the mechanisms that have been crucial for our survival against infection. Rare disorders of either chain of the IFN-γ receptor, but not of IFN-γ itself, have been shown to confer predisposition to myco...

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Source

Identifiers

PMID: 21448974
DOI: 10.1002/humu.21484

Genes

IFNG
IFNGR1
IFNGR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21448974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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