Article
Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity.
Human mutation - 1 Jun 2011
Manry Jérémy, Laval Guillaume, Patin Etienne, Fornarino Simona, Tichit Magali, Bouchier Christiane, Barreiro Luis B, Quintana-Murci Lluis
Abstract excerpt
Identifying how natural selection has affected immunity-related genes can provide insights into the mechanisms that have been crucial for our survival against infection. Rare disorders of either chain of the IFN-γ receptor, but not of IFN-γ itself, have been shown to confer predisposition to mycobacterial disease in patients otherwise normally resistant to most viruses. Here, we defined the levels of naturally...
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