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Article

Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain.

The Journal of biological chemistry - 25 Sept 2015

Barfoot Tasida, Herdendorf Timothy J, Behning Bryanna R, Stohr Bradley A, Gao Yang, Kreuzer Kenneth N, Nelson Scott W

Abstract excerpt

Rad50 and Mre11 form a complex involved in the detection and processing of DNA double strand breaks. Rad50 contains an anti-parallel coiled-coil with two absolutely conserved cysteine residues at its apex. These cysteine residues serve as a dimerization domain and bind a Zn(2+) cation in a tetrathiolate coordination complex known as the zinc-hook. Mutation of the zinc-hook in bacteriophage T4 is lethal,...

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Identifiers

PMID: 26242734
DOI: 10.1074/jbc.M115.675132
PMCID: PMC4583041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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