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Article

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Nature structural & molecular biology - 4 Sept 2011

Hohl Marcel, Kwon Youngho, Galván Sandra Muñoz, Xue Xiaoyu, Tous Cristina, Aguilera Andrés, Sung Patrick, Petrini John H J

Abstract excerpt

The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response. The complex comprises the globular DNA-binding domain and the Rad50 hook domain, which are linked by a long and extended Rad50 coiled-coil domain. In this study, we constructed rad50 alleles encoding truncations of the coiled-coil domain to determine which Mre11 complex functions required...

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Identifiers

PMID: 21892167
DOI: 10.1038/nsmb.2116
PMCID: PMC3190017

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