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Article

Basic-patch mutations in bacteriophage T4 Rad50 uncouple ATPase activation from processive nuclease activity.

Bioscience reports - 19 Aug 2026

Teklemariam Tibebe A, Finnerty Ryan M, Coats Jennifer B, Nelson Scott W

Abstract excerpt

The Mre11/Rad50 (MR) complex uses adenosine triphosphate (ATP) binding and hydrolysis to coordinate the recognition and processing of DNA double-strand breaks. Although Mre11 and DNA stimulate the relatively slow ATPase activity of Rad50, the mechanism by which this occurs remains incompletely understood. In the present study, we investigated a basic patch on bacteriophage T4 Rad50, consisting of Arg154, Arg155,...

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Identifiers

PMID: 42417150
DOI: 10.1042/BSR20260367
PMCID: PMC13402864

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