Article
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.
Genes & development - 1 Mar 2014
Roset Ramon, Inagaki Akiko, Hohl Marcel, Brenet Fabienne, Lafrance-Vanasse Julien, Lange Julian, Scandura Joseph M, Tainer John A, Keeney Scott, Petrini John H J
Abstract excerpt
The Mre11 complex (Mre11, Rad50, and Nbs1) is a central component of the DNA damage response (DDR), governing both double-strand break repair and DDR signaling. Rad50 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain. Mutations that inactivate the hook domain produce a null phenotype. In this study, we analyzed mutants with reduced hook domain function in an effort to...
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