Article
Interdependence of the rad50 hook and globular domain functions.
Molecular cell - 5 Feb 2015
Hohl Marcel, Kochańczyk Tomasz, Tous Cristina, Aguilera Andrés, Krężel Artur, Petrini John H J
Abstract excerpt
Rad50 contains a conserved Zn(2+) coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ablation phenocopies Rad50 deficiency in all respects. Here, we focused on rad50 mutations flanking the Zn(2+)-coordinating hook cysteines. These mutants impaired hook-media...
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