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Article

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.

Nature - 1 Aug 2002

Hopfner Karl-Peter, Craig Lisa, Moncalian Gabriel, Zinkel Robert A, Usui Takehiko, Owen Barbara A L, Karcher Annette, Henderson Brendan, Bodmer Jean-Luc, McMurray Cynthia T, Carney James P, Petrini John H J, Tainer John A

Abstract excerpt

The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. These functions all imply that the linked binding of two DNA substrates occurs, although the molecular basis for this process remains unknown. Here we present a 2.2 A crystal structure of the Rad50 coiled-coil region that reveals an unexpected...

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PMID: 12152085
DOI: 10.1038/nature00922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.PMID 12152085Read ↗

Interdependence of the rad50 hook and globular domain functions.Semantic proximity Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.Semantic proximity Read ↗

Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.Semantic proximity Read ↗

The Rad50 hook domain is a critical determinant of Mre11 complex functions.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain.Semantic proximity Read ↗

Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?Semantic proximity Read ↗

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.Semantic proximity Read ↗

A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and HumansSemantic proximity Read ↗

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.Semantic proximity Read ↗

Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complexSemantic proximity Read ↗

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