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Article

Autoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.

The Journal of biological chemistry - 19 Sept 2014

Gao Yang, Nelson Scott W

Abstract excerpt

Mre11 and Rad50 form a stable complex (MR) and work cooperatively in repairing DNA double strand breaks. In the bacteriophage T4, Rad50 (gene product 46) enhances the nuclease activity of Mre11 (gene product 47), and Mre11 and DNA in combination stimulate the ATPase activity of Rad50. The structural basis for the cross-activation of the MR complex has been elusive. Various crystal structures of the MR complex...

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Identifiers

PMID: 25077970
DOI: 10.1074/jbc.M114.583625
PMCID: PMC4176212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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