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Article

Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions.

Journal of molecular biology - 1 May 2020

Rahman Samiur, Beikzadeh Mahtab, Canny Marella D, Kaur Navneet, Latham Michael P

Abstract excerpt

Naked and protein-blocked DNA ends occur naturally during immune cell development, meiosis, and at telomeres as well as from aborted topoisomerase reactions, collapsed replication forks, and other stressors. Damaged DNA ends are dangerous in cells and if left unrepaired can lead to genomic rearrangement, loss of genetic information, and eventually cancer. Mre11 is part of the Mre11-Rad50-Nbs1 complex that...

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Identifiers

PMID: 32246962
DOI: 10.1016/j.jmb.2020.03.030
PMCID: PMC7231638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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