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Article

Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.

Neurobiology of aging - 1 Aug 2021

Shafer Andrea T, Beason-Held Lori, An Yang, Williams Owen A, Huo Yuankai, Landman Bennett A, Caffo Brian S, Resnick Susan M

Abstract excerpt

The default mode network (DMN) overlaps with regions showing early Alzheimer's Disease (AD) pathology. Age, sex, and apolipoprotein E ɛ4 are the predominant risk factors for developing AD. How these risk factors interact to influence DMN connectivity and connectivity-cognition relationships before the onset of impairment remains unknown. Here, we examined these issues in 475 cognitively normal adults, targeting...

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PMID: 33957555
DOI: 10.1016/j.neurobiolaging.2021.03.013

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