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Article

Alzheimer disease family history impacts resting state functional connectivity.

Annals of neurology - 1 Oct 2012

Wang Liang, Roe Catherine M, Snyder Abraham Z, Brier Matthew R, Thomas Jewell B, Xiong Chengjie, Benzinger Tammie L, Morris John C, Ances Beau M

Abstract excerpt

OBJECTIVE: Offspring whose parents have Alzheimer disease (AD) are at increased risk for developing dementia. Patients with AD typically exhibit disruptions in the default mode network (DMN). The aim of this study was to investigate the effect of a family history of late onset AD on DMN integrity in cognitively normal individuals. In particular, we determined whether a family history effect is detectable in...

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Source

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Identifiers

PMID: 23109152
DOI: 10.1002/ana.23643
PMCID: PMC3490438

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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