Article
CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.
Nutrition and cancer - 1 Jan 2015
Hibler Elizabeth A, Klimentidis Yann C, Jurutka Peter W, Kohler Lindsay N, Lance Peter, Roe Denise J, Thompson Patricia A, Jacobs Elizabeth T
Abstract excerpt
Development of colorectal adenoma and cancer are associated with low circulating 25-hydroxyvitamin D [25(OH)D] levels. However, less is known regarding colorectal neoplasia risk and variation in CYP27B1 or CYP24A1, genes encoding the enzymes responsible for the synthesis and catabolism of 1α,25-hydroxyvitamin D [1,25(OH)2D]. This study examined associations between CYP27B1 and CYP24A1 polymorphisms, circulating...
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