Article
Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes.
Hormones & cancer - 1 Aug 2013
Muindi Josephia R, Adjei Araba A, Wu Zengru R, Olson Isabel, Huang Huayi, Groman Adrienne, Tian Lili, Singh Prashant K, Sucheston Lara E, Johnson Candace S, Trump Donald L, Fakih Marwan G
Abstract excerpt
Cholecalciferol (D(3)) supplementation results in variable increases in serum 25(OH)D(3) levels, however, the influence of genetic polymorphisms on these variable responses is unclear. We measured serum 25(OH)D(3), 24,25(OH)(2)D(3), 1,25(OH)2D(3) and VDBP levels in 50 colorectal cancer (CRC) patients before and during 2,000 IU daily oral D(3) supplementation for six months and in 263 archived CRC serum samples....
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