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Article

CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment.

Cancer causes & control : CCC - 1 Jan 2013

Barry Elizabeth L, Poole Elizabeth M, Baron John A, Makar Karen W, Mott Leila A, Sandler Robert S, Ahnen Dennis J, Bresalier Robert S, McKeown-Eyssen Gail E, Ulrich Cornelia M

Abstract excerpt

PURPOSE: The cytochrome P450 2C9 enzyme (CYP2C9) is involved in metabolism of endogenous compounds, drugs, and procarcinogens. Two common nonsynonymous polymorphisms in CYP2C9 are associated with reduced enzyme activity: CYP2C9*2 (rs1799853, R144C) and CYP2C9*3 (rs1057910, I359L). METHODS: We investigated whether CYP2C9 genotype was associated with risk of colorectal adenoma and/or modified associations with...

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Identifiers

PMID: 23081681
DOI: 10.1007/s10552-012-0088-6
PMCID: PMC3529799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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