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Article

CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.

Cancer research - 15 Apr 2013

Jacobs Elizabeth T, Van Pelt Chad, Forster Ryan E, Zaidi Wasiq, Hibler Elizabeth A, Galligan Michael A, Haussler Mark R, Jurutka Peter W

Abstract excerpt

Vitamin D is a well-studied agent for cancer chemoprevention and treatment. Its chief circulating metabolite, 25-hydroxyvitamin D, is converted into the active hormone 1,25-dihydroxyvitamin D (1,25D) by the cytochrome P450 enzyme CYP27B1 in kidney and other tissues. 1,25D is then deactivated by CYP24A1 and ultimately catabolized. Colorectal carcinoma cells express CYP27B1 and CYP24A1 that locally regulate 1,25D...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23423976
DOI: 10.1158/0008-5472.CAN-12-4134
PMCID: PMC3630267

Genes

VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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