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Article

CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.

Cancer research - 15 Apr 2013

Jacobs Elizabeth T, Van Pelt Chad, Forster Ryan E, Zaidi Wasiq, Hibler Elizabeth A, Galligan Michael A, Haussler Mark R, Jurutka Peter W

Abstract excerpt

Vitamin D is a well-studied agent for cancer chemoprevention and treatment. Its chief circulating metabolite, 25-hydroxyvitamin D, is converted into the active hormone 1,25-dihydroxyvitamin D (1,25D) by the cytochrome P450 enzyme CYP27B1 in kidney and other tissues. 1,25D is then deactivated by C...

Read the complete abstract on PubMed

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Share to Cell Line, Tumor
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Steroid Hydroxylases

Share to Transcription, Genetic

Share to Vitamin D

Share to Vitamin D3 24-Hydroxylase

Source

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Identifiers

PMID: 23423976
DOI: 10.1158/0008-5472.CAN-12-4134
PMCID: PMC3630267

Genes

VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23423976-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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